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1

Autophagy: A lysosomal degradation pathway with a central role in health and disease

Eeva-Liisa Eskelinen, Paul Saftig

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 798 KB

english, 2009

2

Autophagy in neuronal cells: general principles and physiological and pathological functions

Damme, Markus, Suntio, Taina, Saftig, Paul, Eskelinen, Eeva-Liisa

Journal:

Acta Neuropathologica

Year:

2015

Language:

english

File:

PDF, 2.32 MB

english, 2015

3

10.1038/19083

De Strooper, Bart, Kopan, Raphael, Annaert, Wim, Cupers, Philippe, Saftig, Paul, Craessaerts, Katleen, Mumm, Jeffrey S., Schroeter, Eric H., Schrijvers, Vincent, Wolfe, Michael S., Ray, William J., Go

Journal:

Year:

1999

Language:

english

File:

PDF, 543 KB

english, 1999

4

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Saftig, Paul, Klumperman, Judith

Journal:

Nature Reviews Molecular Cell Biology

Year:

2009

Language:

english

File:

PDF, 711 KB

english, 2009

5

Regulated intramembrane proteolysis—A story about sheddases and I-CliPs

Willem G. Annaert, Paul Saftig

Journal:

Seminars in Cell & Developmental Biology

Year:

2009

Language:

english

File:

PDF, 74 KB

english, 2009

6

Impaired Osteoclastic Bone Resorption Leads to Osteopetrosis in Cathepsin-K-Deficient Mice

Paul Saftig, Ernst Hunziker, Olaf Wehmeyer, Sheila Jones, Alan Boyde, Winfried Rommerskirch, Jorg Detlev Moritz, Peter Schu and Kurt Von Figura

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.84 MB

english, 1998

7

Cathepsin K Deficiency Suppresses Disuse-Induced Bone Loss

Moriya, Shuichi, Izu, Yayoi, Arayal, Smriti, Kawasaki, Makiri, Hata, Koki, Pawaputanon Na Mahasarakhahm, Chantida, Izumi, Yuichi, Saftig, Paul, Kaneko, Kazuo, Noda, Masaki, Ezura, Yoichi

Journal:

Journal of Cellular Physiology

Year:

2016

Language:

english

File:

PDF, 606 KB

english, 2016

8

Turn up the lysosome

Saftig, Paul, Haas, Albert

Journal:

Nature Cell Biology

Year:

2016

Language:

english

File:

PDF, 227 KB

english, 2016

9

Thyroid functions of mouse cathepsins B, K, and L

Friedrichs, Bianca, Tepel, Carmen, Reinheckel, Thomas, Deussing, Jan, von Figura, Kurt, Herzog, Volker, Peters, Christoph, Saftig, Paul, Brix, Klaudia

Journal:

Journal of Clinical Investigation

Year:

2003

Language:

english

File:

PDF, 5.92 MB

english, 2003

10

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

Beel, Sander, Moisse, Matthieu, Damme, Markus, De Muynck, Louis, Robberecht, Wim, Van Den Bosch, Ludo, Saftig, Paul, Van Damme, Philip

Journal:

Human Molecular Genetics

Year:

2017

Language:

english

File:

PDF, 1.82 MB

english, 2017

11

Intermittent Fasting Preserves Beta-Cell Mass in Obesity-induced Diabetes via the Autophagy-Lysosome Pathway

Liu, Haiyan, Javaheri, Ali, Godar, Rebecca J., Murphy, John, Ma, Xiucui, Rohatgi, Nidhi, Mahadevan, Jana, Hyrc, Krzysztof, Saftig, Paul, Marshall, Connie, McDaniel, Michael L., Remedi, Maria S., Razan

Journal:

Year:

2017

Language:

english

File:

PDF, 3.50 MB

english, 2017

12

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

Valerie Cullen, S. Pablo Sardi, Juliana Ng, You-Hai Xu, Ying Sun, Julianna J. Tomlinson, Piotr Kolodziej, Ilana Kahn, Paul Saftig, John Woulfe, Jean-Christophe Rochet, Marcie A. Glicksman, Seng H. Che

Journal:

Annals of Neurology

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

13

Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice

Jacques P.M Schellens, Paul Saftig, Kurt von Figura, Vincent Everts

Journal:

Cell Biology International

Year:

2003

Language:

english

File:

PDF, 393 KB

english, 2003

14

The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

Dongwei Zhang, Nelson Leung, Ekkehard Weber, Paul Saftig, Dieter Brömme

Journal:

Respiratory Research

Year:

2011

Language:

english

File:

PDF, 4.79 MB

english, 2011

15

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

Stephanie Dauth, Ruxandra F Sîrbulescu, Silvia Jordans, Maren Rehders, Linda Avena, Julia Oswald, Alexander Lerchl, Paul Saftig, Klaudia Brix

Journal:

BMC Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.03 MB

english, 2011

16

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion proteinin vivo

Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel

Journal:

Molecular Neurodegeneration

Year:

2011

Language:

english

File:

PDF, 4.17 MB

english, 2011

17

The proteome of lysosomes

Bernd A. Schröder, Christian Wrocklage, Andrej Hasilik, Paul Saftig

Journal:

Year:

2010

Language:

english

File:

PDF, 389 KB

english, 2010

18

LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling

Jörg Stypmann, Paul M.L. Janssen, Jürgen Prestle, Markus A. Engelen, Harald Kögler, Renate Lüllmann-Rauch, Lars Eckardt, Kurt von Figura, Jobst Landgrebe, Anna Mleczko, Paul Saftig

Journal:

Basic Research in Cardiology

Year:

2006

Language:

english

File:

PDF, 953 KB

english, 2006

19

Spermatogenesis proceeds normally in mice without linker histone H1t

Birgit Drabent, Paul Saftig, Christa Bode, Detlef Doenecke

Journal:

Histochemistry and Cell Biology

Year:

2000

Language:

english

File:

PDF, 660 KB

english, 2000

20

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+current

Tobias Huth, Andrea Rittger, Paul Saftig, Christian Alzheimer

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

21

Altered morphological and electrophysiological properties of Cajal–Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice

Werner Kilb, Dieter Hartmann, Paul Saftig, Heiko J. Luhmann

Journal:

European Journal of Neuroscience

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

22

Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2

Marcelo G. Binker, Laura I. Cosen-Binker, Mauricio R. Terebiznik, Gustavo V. Mallo, Shannon E. McCaw, Eeva-Liisa Eskelinen, Marion Willenborg, John H. Brumell, Paul Saftig, Sergio Grinstein, Scott D.

Journal:

Cellular Microbiology

Year:

2007

Language:

english

File:

PDF, 1.90 MB

english, 2007

23

Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice

Tokiko Shimizu, Yoshinori Hayashi, Ryo Yamasaki, Jun Yamada, Jian Zhang, Kiyoharu Ukai, Masato Koike, Kazunori Mine, Kurt Von Figura, Christoph Peters, Paul Saftig, Takaichi Fukuda, Yasuo Uchiyama, Hi

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 521 KB

english, 2005

24

Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis

Sabrina Jabs, Arne Quitsch, Reijo Käkelä, Bettina Koch, Jaana Tyynelä, Helmut Brade, Markus Glatzel, Steven Walkley, Paul Saftig, Marie T. Vanier, Thomas Braulke

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 1.50 MB

english, 2008

25

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing

Sabine Rabe, Julia Reichwald, Domenico Ammaturo, Bart de Strooper, Paul Saftig, Ulf Neumann, Matthias Staufenbiel

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

26

Proteases involved in MHC dass II antigen presentation

José A. Villadangos, Rebecca A. R. Bryant, Jan Deussing, Christoph Driessen, Ana-Maria Lennon-Duménil, Richard J. Riese, Wera Roth, Paul Saftig, Guo-Ping Shi, Harold A. Chapman, Christoph Peters, Hidd

Journal:

Immunological Reviews

Year:

1999

Language:

english

File:

PDF, 6.10 MB

english, 1999

27

The NH2-Terminal Transmembrane and Lumenal Domains of LGP85 are Needed for the Formation of Enlarged Endosomes/Lysosomes

Toshio Kuronita, Toshiyuki Hatano, Atsuko Furuyama, Yuko Hirota, Naoko Masuyama, Paul Saftig, Masaru Himeno, Hideaki Fujita, Yoshitaka Tanaka

Journal:

Year:

2005

Language:

english

File:

PDF, 6.30 MB

english, 2005

28

Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP-2

Eeva-Liisa Eskelinen, Ana Maria Cuervo, Matthew R.G. Taylor, Ichizo Nishino, Janice S. Blum, J. Fred Dice, Ignacio V. Sandoval, Jennifer Lippincott-Schwartz, J. Thomas August, Paul Saftig

Journal:

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

29

10.1038/34910

De Strooper, Bart, Saftig, Paul, Craessaerts, Katleen, Vanderstichele, Hugo, Guhde, Gundula, Annaert, Wim, Von Figura, Kurt, Van Leuven, Fred

Journal:

Year:

1998

Language:

english

File:

PDF, 382 KB

english, 1998

30

10.1038/35022595

Saftig, Paul, Tanaka, Yoshitaka, Guhde, Gundula, Suter, Anke, Eskelinen, Eeva-Liisa, Hartmann, Dieter, Lüllmann-Rauch, Renate, Janssen, Paul M. L., Blanz, Judith, von Figura, Kurt

Journal:

Year:

2000

Language:

english

File:

PDF, 517 KB

english, 2000

31

No endogenous Aβ production in presenilin-deficient fibroblasts

Nyabi, Omar, Pype, Stefan, Mercken, Marc, Herreman, An, Saftig, Paul, Craessaerts, Katleen, Serneels, Lutgarde, Annaert, Wim, De Strooper, Bart

Journal:

Nature Cell Biology

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

32

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

Weskamp, Gisela, Ford, Jill W, Sturgill, Jamie, Martin, Steve, Docherty, Andrew J P, Swendeman, Steven, Broadway, Neil, Hartmann, Dieter, Saftig, Paul, Umland, Shelby

Journal:

Nature Immunology

Year:

2006

Language:

english

File:

PDF, 237 KB

english, 2006

33

Live longer with LAMP-2

Saftig, Paul, Eskelinen, Eeva-Liisa

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 389 KB

english, 2008

34

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

Reiss, Karina, Maretzky, Thorsten, Ludwig, Andreas, Tousseyn, Thomas, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

35

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

Reiss, Karina, Maretzky, Thorsten, Ludwig, Andreas, Tousseyn, Thomas, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 38 KB

english, 2005

36

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

Li, Nianyu, Wang, Yao, Forbes, Karen, Vignali, Kate M, Heale, Bret S, Saftig, Paul, Hartmann, Dieter, Black, Roy A, Rossi, John J, Blobel, Carl P

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 401 KB

english, 2007

37

LAMP proteins are required for fusion of lysosomes with phagosomes

Huynh, Kassidy K, Eskelinen, Eeva-Liisa, Scott, Cameron C, Malevanets, Anatoly, Saftig, Paul, Grinstein, Sergio

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 447 KB

english, 2007

38

ADAM10-Mediated E-Cadherin Release Is Regulated by Proinflammatory Cytokines and Modulates Keratinocyte Cohesion in Eczematous Dermatitis

Maretzky, Thorsten, Scholz, Felix, Köten, Bente, Proksch, Ehrhardt, Saftig, Paul, Reiss, Karina

Journal:

The Journal of Investigative Dermatology

Year:

2008

Language:

english

File:

PDF, 3.13 MB

english, 2008

39

Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

Wu, Gen Sheng, Saftig, Paul, Peters, Christoph, El-Deiry, Wafik S

Journal:

Year:

1998

Language:

english

File:

PDF, 1.09 MB

english, 1998

40

Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis

Marlies Knipper, Cathrin Claussen, Lukas Rüttiger, Ulrike Zimmermann, Renate Lüllmann-Rauch, Eeva-Liisa Eskelinen, Jenny Schröder, Michael Schwake, Paul Saftig

Journal:

The Journal of Physiology

Year:

2006

Language:

english

File:

PDF, 666 KB

english, 2006

41

Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

Vincent Everts, Wolf Korper, Kees A Hoeben, Ineke DC Jansen, Dieter Bromme, Kitty BJM Cleutjens, Sylvia Heeneman, Christoph Peters, Thomas Reinheckel, Paul Saftig, Wouter Beertsen

Journal:

Journal of Bone and Mineral Research

Year:

2006

Language:

english

File:

PDF, 624 KB

english, 2006

42

Implication of APP secretases in notch signaling

Dieter Hartmann, Jos Tournoy, Paul Saftig, Wim Annaert, Bart De Strooper

Journal:

Journal of Molecular Neuroscience

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

43

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

Xu, Haixia, Zhu, Jimmy, Smith, Sinead, Foldi, Julia, Zhao, Baohong, Chung, Allen Y, Outtz, Hasina, Kitajewski, Jan, Shi, Chao, Weber, Silvio, Saftig, Paul, Li, Yueming, Ozato, Keiko, Blobel, Carl P, I

Journal:

Nature Immunology

Year:

2012

Language:

english

File:

PDF, 943 KB

english, 2012

44

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

Johannes Prox, Andrea Rittger, Paul Saftig

Journal:

Experimental Brain Research

Year:

2012

Language:

english

File:

PDF, 565 KB

english, 2012

45

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

Verena Arndt, Nikolaus Dick, Riga Tawo, Michael Dreiseidler, Daniela Wenzel, Michael Hesse, Dieter O. Fürst, Paul Saftig, Robert Saint, Bernd K. Fleischmann, Michael Hoch, Jörg Höhfeld

Journal:

Current Biology

Year:

2010

Language:

english

File:

PDF, 850 KB

english, 2010

46

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

Paul Saftig, Karina Reiss

Journal:

European Journal of Cell Biology

Year:

2011

Language:

english

File:

PDF, 686 KB

english, 2011

47

Klotho is a substrate for α-, β- and γ-secretase

Laura Bloch, Olga Sineshchekova, Daniela Reichenbach, Karina Reiss, Paul Saftig, Makoto Kuro-o, Christoph Kaether

Journal:

Year:

2009

Language:

english

File:

PDF, 407 KB

english, 2009

48

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

Jörg Behnke, Janna Schneppenheim, Friedrich Koch-Nolte, Friedrich Haag, Paul Saftig, Bernd Schröder

Journal:

Year:

2011

Language:

english

File:

PDF, 1.72 MB

english, 2011

49

Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment

Karen Caeyenberghs, Detlef Balschun, Diego Prieto Roces, Michael Schwake, Paul Saftig, Rudi D'Hooge

Journal:

Neurobiology of Disease

Year:

2006

Language:

english

File:

PDF, 522 KB

english, 2006

50

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

Tobias Huth, Karoline Schmidt-Neuenfeldt, Andrea Rittger, Paul Saftig, Karina Reiss, Christian Alzheimer

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 586 KB

english, 2009